By activating the hydrolyzing enzymes and increasing the release of lysosomes of cells durabolin price, reduces the viscosity of sputum. It increases motor activity of ciliated epithelium, increases mucociliary transport. Once inside the action occurs within 30 minutes, while rectal administration -. 10-30 minutes and lasts for 6-12 hours For parenteral administration, the action comes quickly and lasts for 6-10 hours.
Absorption – high (at any of the introduction), hours, the connection with plasma proteins – 80%. It penetrates the , placental barrier, excreted in breast milk. Metabolism – in liver forms dibromantranilovuyu and glucuronic acid conjugates. . T1 / 2 – 7-12 hours excreted by the kidneys: 90% in the form of water-soluble metabolites in unmodified form – 5%. T1 / 2 is increased in severe renal failure, it does not change with impaired hepatic function.
Respiratory system diseases with the formation of viscous mucus: acute and chronic bronchitis, pneumonia, chronic obstructive pulmonary disease, bronchial asthma with obstruction of sputum discharge, bronchiectasis.
: Hypersensitivity to ambroxol and / or other components of the drug, pregnancy durabolin price. Children under 5 years old. With care – gastric ulcer and duodenal ulcers, kidney and / or liver failure.
Dosing and Administration
Inside, during a meal, with a small amount of liquid. Adults and children over 12 years: 30 mg 3 times a day during the first 2-3 days, followed by 30 mg 2 times or 15 mg 3 times a day. In severe cases, the dose is not reduced during the course of treatment. Children 5-12 years appoint 15 mg 2-3 times a day. Not recommended for use without a doctor’s appointment more than 4-5 days.
: Allergic reactions: skin rash, urticaria, angioedema, in some cases – allergic contact dermatitis, anaphylactic shock. Rarely – weakness, headache, diarrhea, dry mouth and respiratory tract, rash, runny nose, constipation, dysuria. With prolonged use at high doses – heartburn, gastralgia, nausea, vomiting.
Symptoms: nausea, vomiting, diarrhea, dyspepsia. Treatment: artificial vomiting, gastric lavage in the first 1-2 hours after taking the drug; reception of fat-containing products. Symptomatic therapy.
Interaction with other drugs
combined use of antitussive drugs durabolin price (eg, containing codeine) leads to difficulty sputum discharge on the background to reduce coughing. Increases penetration in bronchial secretion of amoxicillin, cefuroxime, erythromycin and doxycycline.