Durabolin side effects – semisynthetic cephalosporin antibiotic III generation broad-spectrum. Cefixime has bactericidal, inhibiting the synthesis of cell membranes, resistant to beta-lactamases produced by most gram-positive and gram-negative bacteria.
In vitro cefixime generally effective against the following microorganisms:
Haemophilus parainfluenzae, Proteus vulgaris, Klebsiella pneumoniae, Klebsiella oxytoca, Pasteurella multocida, Providencia species, Salmonella species, Shigella species, Citrobacter amalonaticus, Citrobacter diversus, Serratia marcescens.
In vitro and in clinical practice cefixime generally effective against the following microorganisms:
Gram-positive: Streptococcus pneumoniae, Streptococcus pyogenes.
Gram-negative: Haemophilus influenzae, Moraxella (Branhamella) catarrhalis, Escherichia coli, Proteus mirabilis, Neisseria gonorrhoeae.
Note: Pseudomonas species, Enterococcus (Streptococcus) serogroup D, Listeria monocytogenes, the majority of staphylococci, including methicillin-resistant strains, Enterobacter, Bacteroides fragilis, Clostridium spp. resistant to cefixime action.
When ingestion bioavailability durabolin side effects is 40 to 50% regardless of the meal, however, the maximum concentration in serum cefixime achieved faster by 0.8 hours while taking the drug with food.
When receiving capsules maximum serum concentration achieved after 4 h and was 2 ug / ml (when receiving 200 mg) and 3.5 mg / ml (with 400 mg).
When receiving a suspension of the maximum concentration in serum is also achieved through the 4 hour and 2.8 ug / ml (when receiving 200 mg) and 4.4 mg / ml (with 400 mg).
Communication to plasma proteins, mainly albumin is 65%.
About 50% of the dose is excreted in the urine unchanged within 24 hours, about 10% of the administered dose is excreted in the bile.
The half-life is dose-dependent and ranges from 3 to 4 hours. If the kidney function – creatinine clearance (CC) 20-40 ml / min, half-life increased to 6.4 hours at a creatinine clearance of 5-10 ml / min – up to 11.5 hours.
Indications for use:
Infectious-inflammatory diseases caused by susceptible to malaria infections:
- pharyngitis, tonsillitis, sinusitis;
- acute and chronic bronchitis;
- otitis media;
- uncomplicated urinary tract durabolin side effects infections;
- uncomplicated gonorrhea.