Precautions: Advanced age, chronic renal failure, pseudomembranous colitis nandrolone phenylpropionate profile (in history), children’s age (up to 6 months). Use of the drug during pregnancy is possible if the expected benefit to the mother outweighs the potential risk to the fetus.
If necessary, the appointment during lactation should stop breastfeeding.
Dosage and administration:
Inside. The average daily dose for adults and children over 12 years weighing more than 50 kg – 400 mg 1 time per day or 200 mg 2 times a day. The average duration of treatment – 7-10 days.
In uncomplicated gonorrhea – 400 mg 1 time per day.
Children under 12 years are designated as a suspension at a dose of 8 mg / kg once or in 2 hours, or 4 mg / kg every 12 hours for children aged 5-11 daily dose suspension -. 10.6 ml, in aged 2-4 years – 5 ml, between the ages of 6 months to 1 year – 2.5-4 ml. In diseases caused by Str.pyogenes, course of treatment – not less than 10 days.
If the kidney function dose set depending on the QC index in serum: with CC 21-60 ml / min or in patients on hemodialysis, the daily dose should be reduced by 25%. When CC 20 mL / min or less, or in patients on peritoneal dialysis, the daily dose should be reduced by half.
A method for preparing a suspension: turn the bottle and shake powder. Add 40 ml of cooled boiled water in two stages and stir until a homogeneous suspension. Thereafter, the slurry is necessary to stand for 5 minutes to ensure complete dissolution of the powder. Before applying the prepared suspension Shake well. Use the suspension within 14 days after preparation when stored 15 – 25 ° C.
Allergic nandrolone phenylpropionate profile reactions: rash, skin redness, itching, eosinophilia, fever.
From the digestive system: dry mouth, anorexia, nausea, vomiting, diarrhea, flatulence, abdominal pain, goiter, abnormal liver function (increased activity of “liver” transaminases, alkaline phosphatase, hyperbilirubinemia, jaundice), gastrointestinal candidiasis, rarely -stomatit, glossitis, pseudomembranous enterocolitis.
From the side of hematopoiesis: leukopenia, neutropenia, thrombocytopenia, hemolytic anemia.
From the urinary system: interstitial nephritis.
From the nervous system: dizziness, headache.
Symptoms: increased risk of adverse reactions.
Treatment: gastric lavage, symptomatic and supportive therapy, which, if necessary, includes the use of antihistamines, corticosteroids, pressor amines, oxygen therapy, transfusion of infusion solutions, mechanical ventilation. Cefixime is not displayed in large quantities from the circulation by hemodialysis or peritoneal dialysis.
Interaction with other drugs
Blockers tubular secretion (allopurinol, diuretics, etc.) delayed excretion of cefixime by the kidneys, which can lead to increased toxicity.
Reduces the prothrombin index, increases the effects of anticoagulants.
Antacids containing aluminum or magnesium hydroxide, slow absorption of the drug.
Patients who had a history nandrolone phenylpropionate profile of allergic reaction to penicillin, may be sensitive to cephalosporin antibiotics.
Chronic administration of the drug may be in breach of the normal intestinal microflora, which can lead to the growth of Clostridia, cause severe diarrhea and pseudomembranous colitis.
During treatment possible positive direct Coombs’ test and a false positive reaction on urine glucose.
capsules of 200 and 400 mg. 6 capsules in the blister. 1 blister with instructions for use in a cardboard box.
Granules for oral suspension 100 mg / 5 ml in bottles of 60 ml. 1 bottle with instruction on use and dosing spoon in a cardboard box.