nandrolone phenylpropionate side effects

Relationship to plasma proteins – 97%. The nandrolone phenylpropionate side effects not cross the blood-brain barrier. Almost completely metabiliziruetsya in the liver by conjugation. Write mainly in the bile and kidneys.

Indications
Symptomatic treatment of acute and chronic diarrhea of various origins (allergic, emotional, drug, radiation, changing diet and qualitative composition of food, in violation of metabolism and absorption, and as an adjunct in the diarrhea of infectious origin). Regulation of stool in patients with iliostoma.

Contraindications:
Hypersensitivity to the drug, diverticulosis, intestinal obstruction, ulcerative colitis in the acute stage, acute diarrhea with pseudomembranous enterocolitis, as monotherapy – dysentery and other infections of the gastrointestinal tract; Pregnancy (1 trimester), lactation, loperamide capsules are not indicated for children under 6 years old.

Be wary – hepatic insufficiency.

Dosage and administration:
Adults with acute and chronic diarrhea initially administered 2 capsules (4 mg), followed by 1 capsule (2 mg) after each act of defecation in the case of loose stool.
The maximum daily dose – 8 capsules (16 mg).
Children older than 6 years appoint 1 capsule (2 mg) after each act of defecation in the case of loose stool. The maximum daily dose -. 3 of the capsule (6 mg)
after normalization of stool or chair in the absence hours of treatment should be discontinued.

Side effects
observed, as a rule, only during nandrolone phenylpropionate side effects chronic administration of the drug. There may be headache, and epigastric discomfort, dry mouth, hypovolemia, electrolyte disturbances, bloating, urinary retention. Rarely – drowsiness or insomnia, dizziness, intestinal cramps, nausea, vomiting, constipation. Very rarely – ileus.
Allergic reactions (skin rash).

Overdosing Symptoms: oppression signs of central nervous system function (stupor, incoordination, drowsiness, pupillary constriction, increased skeletal muscle tone, respiratory depression), intestinal obstruction. Treatment: gastric lavage, activated charcoal (in the first 3 hours after drug administration). As a specific antagonist naloxone is used. In case of overdose symptoms should see a doctor immediately. It should be under medical surveillance for at least 48 hours.

The interaction with other drugs
loperamide is a substrate for nandrolone phenylpropionate side effects. The combined use of loperamide (16 mg single dose) together with a single dose (600 mg) quinidine or rinotavira, each of which is an inhibitor of P-glycoprotein leads to two three-time increase of plasma concentrations of loperamide. Caution must be exercised when using loperamide with quinidine rinavirom and P-glycoprotein inhibitors in recommended doses (from 2 mg to 16 mg daily maximum dose) due to the possibility of increasing the main effects. When a single dose of 16 mg of loperamide is taken in conjunction with the 600 mg single dose of saquinavir, loperamide reduces the effect of saquinavir 54%, which may have clinical importance, as reduced therapeutic effect of saquinavir. Action saquinavir on loperamide has no clinical significance. Therefore, when loperamide is used in conjunction with saquinavir, saquinavir therapeutic effect should be monitored. cypionat 250

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